What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule research compound, not a peptide. It is studied as a membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme in the nicotinamide and S-adenosylmethionine pathways. It is supplied as a powder for in-vitro laboratory research use only.
5-Amino-1MQ research
Published work on 5-Amino-1MQ is qualitative in the framing below. Each item describes the focus of the research itself, not an outcome for any person.
- NNMT inhibition. Research has characterized 5-Amino-1MQ as a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase in enzymatic and cell assays.
- Adipocyte and metabolic research. Studies in rodent models have examined adipose tissue and metabolic endpoints following NNMT inhibition.
- Muscle stem-cell research. Investigations have explored NNMT inhibition in aged muscle stem-cell models.
- Nicotinamide / NAD+ pathway research. Studies have examined effects on nicotinamide and S-adenosylmethionine levels in research systems.
5-Amino-1MQ specifications
| CAS Number | 42464-96-0 |
|---|---|
| Synonyms | 5-amino-1-methylquinolin-1-ium, 5-A-1MQ |
| Molecular Formula | Provided on batch COA |
| Molecular Weight | Provided on batch COA |
| Compound Class | Small-molecule quinolinium (non-peptide) |
| Purity | ≥99% by HPLC |
| Physical Form | Powder |
| Solubility | Soluble in water and DMSO |
| Storage | Store at -20°C, desiccated; protect from light |
| Shelf Life | 24+ months sealed at -20°C |
| Presentation | 50 mg per vial |
5-Amino-1MQ reconstitution & storage
Store the sealed vial at -20°C, desiccated and protected from light. Dissolve in sterile water or DMSO as required by the assay; do not shake. After preparation, store solutions refrigerated at 2 to 8°C and use within the period indicated on the batch COA. For laboratory research handling only.
5-Amino-1MQ certificate of analysis (COA)
A batch-specific Certificate of Analysis accompanies every order, as it does for all research peptides for sale from PeptideX1. The COA documents identity and purity by HPLC for the lot you receive, along with the molecular data listed as provided on batch COA above. Third-party analytical reports are available on request.
5-Amino-1MQ research references
- Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. 2018. PubMed
- Neelakantan H, Brightwell CR, Graber TG, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochemical Pharmacology. 2019. PubMed
- PubChem compound record for 5-amino-1-methylquinolinium. National Library of Medicine. PubChem
5-Amino-1MQ FAQ
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule research compound, not a peptide. It is studied as a membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme in the nicotinamide and S-adenosylmethionine pathways. It is supplied as a powder for in-vitro laboratory research use only.
What purity does PeptideX1 5-Amino-1MQ meet?
Each batch is ≥99% purity by HPLC, verified per batch on the accompanying Certificate of Analysis.
Is a Certificate of Analysis included?
Yes. A batch-specific Certificate of Analysis is included with every order.
How is it shipped and stored?
It ships as a sealed powder, sealed and desiccated. Store the sealed vial at -20°C and protect it from light.
Is 5-Amino-1MQ a peptide?
No. It is a small-molecule quinolinium compound. It is listed alongside our peptides because it is studied in the same metabolic-research settings, and it is held to the same HPLC purity and batch-COA standard.
Is this product for human use?
No. It is sold strictly for in-vitro laboratory research use only. It is not for human or veterinary use.